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Ocular hypertension

MedGen UID:
10423
•Concept ID:
C0028840
•
Disease or Syndrome
Synonyms: Hypertension, Ocular; Hypertensions, Ocular; Ocular Hypertension; Ocular Hypertensions
SNOMED CT: OH - ocular hypertension (4210003); OHT - ocular hypertension (4210003); Ocular hypertension (4210003)
 
Monarch Initiative: MONDO:0006875

Definition

Abnormally high intraocular pressure. [from NCI]

Professional guidelines

PubMed

Current practice in the management of ocular toxoplasmosis.
Yogeswaran K, Furtado JM, Bodaghi B, Matthews JM; International Ocular Toxoplasmosis Study Group, Smith JR
Br J Ophthalmol 2023 Jul;107(7):973-979. Epub 2022 Feb 23 doi: 10.1136/bjophthalmol-2022-321091. PMID: 35197262
Pathophysiology and management of glaucoma and ocular hypertension related to trauma.
Razeghinejad R, Lin MM, Lee D, Katz LJ, Myers JS
Surv Ophthalmol 2020 Sep-Oct;65(5):530-547. Epub 2020 Feb 11 doi: 10.1016/j.survophthal.2020.02.003. PMID: 32057763
Glaucoma Suspect: Diagnosis and Management.
Chang RT, Singh K
Asia Pac J Ophthalmol (Phila) 2016 Jan-Feb;5(1):32-7. doi: 10.1097/APO.0000000000000173. PMID: 26886117

Recent clinical studies

Etiology

Pediatric glaucoma suspects: characteristics and outcomes.
Kletke SN, Mills MD, Tomlinson LA, Yu Y, Ying GS, Binenbaum G
J AAPOS 2022 Oct;26(5):236.e1-236.e6. Epub 2022 Sep 14 doi: 10.1016/j.jaapos.2022.05.010. PMID: 36113699
OCULAR HYPERTENSION AND GLAUCOMA FOLLOWING VITRECTOMY: A Systematic Review.
Miele A, Govetto A, Fumagalli C, Donati S, Biagini I, Azzolini C, Rizzo S, Virgili G
Retina 2018 May;38(5):883-890. doi: 10.1097/IAE.0000000000001651. PMID: 28426628
Uveitic Ocular Hypertension and Glaucoma.
Cunningham ET Jr, Zierhut M
Ocul Immunol Inflamm 2017 Dec;25(6):737-739. doi: 10.1080/09273948.2017.1415077. PMID: 29265966
Corneal transplantation and glaucoma.
Haddadin RI, Chodosh J
Semin Ophthalmol 2014 Sep-Nov;29(5-6):380-96. doi: 10.3109/08820538.2014.959201. PMID: 25325864
Pseudophakic glaucoma.
van Oye R, Gelisken O
Int Ophthalmol 1985 Sep;8(3):183-6. doi: 10.1007/BF00136496. PMID: 4066161

Diagnosis

Pediatric glaucoma suspects: characteristics and outcomes.
Kletke SN, Mills MD, Tomlinson LA, Yu Y, Ying GS, Binenbaum G
J AAPOS 2022 Oct;26(5):236.e1-236.e6. Epub 2022 Sep 14 doi: 10.1016/j.jaapos.2022.05.010. PMID: 36113699
Uveitic Ocular Hypertension and Glaucoma.
Cunningham ET Jr, Zierhut M
Ocul Immunol Inflamm 2017 Dec;25(6):737-739. doi: 10.1080/09273948.2017.1415077. PMID: 29265966
Central corneal thickness in glaucoma.
Sng CC, Ang M, Barton K
Curr Opin Ophthalmol 2017 Mar;28(2):120-126. doi: 10.1097/ICU.0000000000000335. PMID: 27764022
Glaucoma Suspect: Diagnosis and Management.
Chang RT, Singh K
Asia Pac J Ophthalmol (Phila) 2016 Jan-Feb;5(1):32-7. doi: 10.1097/APO.0000000000000173. PMID: 26886117
The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma.
Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Kass MA
Arch Ophthalmol 2002 Jun;120(6):714-20; discussion 829-30. doi: 10.1001/archopht.120.6.714. PMID: 12049575

Therapy

Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial: Six-Year Results of Primary Selective Laser Trabeculoplasty versus Eye Drops for the Treatment of Glaucoma and Ocular Hypertension.
Gazzard G, Konstantakopoulou E, Garway-Heath D, Adeleke M, Vickerstaff V, Ambler G, Hunter R, Bunce C, Nathwani N, Barton K; LiGHT Trial Study Group
Ophthalmology 2023 Feb;130(2):139-151. Epub 2022 Sep 17 doi: 10.1016/j.ophtha.2022.09.009. PMID: 36122660
Topical corticosteroids for dry eye.
Liu SH, Saldanha IJ, Abraham AG, Rittiphairoj T, Hauswirth S, Gregory D, Ifantides C, Li T
Cochrane Database Syst Rev 2022 Oct 21;10(10):CD015070. doi: 10.1002/14651858.CD015070.pub2. PMID: 36269562Free PMC Article
Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial.
Gazzard G, Konstantakopoulou E, Garway-Heath D, Garg A, Vickerstaff V, Hunter R, Ambler G, Bunce C, Wormald R, Nathwani N, Barton K, Rubin G, Buszewicz M; LiGHT Trial Study Group
Lancet 2019 Apr 13;393(10180):1505-1516. Epub 2019 Mar 9 doi: 10.1016/S0140-6736(18)32213-X. PMID: 30862377Free PMC Article
Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma: A Systematic Review and Network Meta-analysis.
Li T, Lindsley K, Rouse B, Hong H, Shi Q, Friedman DS, Wormald R, Dickersin K
Ophthalmology 2016 Jan;123(1):129-40. Epub 2015 Oct 31 doi: 10.1016/j.ophtha.2015.09.005. PMID: 26526633Free PMC Article
The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.
Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Gordon MO
Arch Ophthalmol 2002 Jun;120(6):701-13; discussion 829-30. doi: 10.1001/archopht.120.6.701. PMID: 12049574

Prognosis

OCULAR HYPERTENSION AND GLAUCOMA FOLLOWING VITRECTOMY: A Systematic Review.
Miele A, Govetto A, Fumagalli C, Donati S, Biagini I, Azzolini C, Rizzo S, Virgili G
Retina 2018 May;38(5):883-890. doi: 10.1097/IAE.0000000000001651. PMID: 28426628
Optic disk hemorrhage in health and disease.
Razeghinejad MR, Nowroozzadeh MH
Surv Ophthalmol 2017 Nov-Dec;62(6):784-802. Epub 2017 Apr 8 doi: 10.1016/j.survophthal.2017.04.001. PMID: 28400276
Corneal transplantation and glaucoma.
Haddadin RI, Chodosh J
Semin Ophthalmol 2014 Sep-Nov;29(5-6):380-96. doi: 10.3109/08820538.2014.959201. PMID: 25325864
The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.
Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Gordon MO
Arch Ophthalmol 2002 Jun;120(6):701-13; discussion 829-30. doi: 10.1001/archopht.120.6.701. PMID: 12049574
Pseudophakic glaucoma.
van Oye R, Gelisken O
Int Ophthalmol 1985 Sep;8(3):183-6. doi: 10.1007/BF00136496. PMID: 4066161

Clinical prediction guides

The natural history of untreated ocular hypertension and glaucoma.
Lauwers A, Barbosa Breda J, Stalmans I
Surv Ophthalmol 2023 May-Jun;68(3):388-424. Epub 2022 Dec 21 doi: 10.1016/j.survophthal.2022.12.001. PMID: 36563707
Current intravitreal therapy and ocular hypertension: A review.
Sudhalkar A, Bilgic A, Vasavada S, Kodjikian L, Mathis T, de Ribot FM, Papakostas T, Vasavada V, Vasavada V, Srivastava S, Bhojwani D, Ghia P, Sudhalkar A
Indian J Ophthalmol 2021 Feb;69(2):236-243. doi: 10.4103/ijo.IJO_1028_20. PMID: 33463565Free PMC Article
Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial.
Gazzard G, Konstantakopoulou E, Garway-Heath D, Garg A, Vickerstaff V, Hunter R, Ambler G, Bunce C, Wormald R, Nathwani N, Barton K, Rubin G, Buszewicz M; LiGHT Trial Study Group
Lancet 2019 Apr 13;393(10180):1505-1516. Epub 2019 Mar 9 doi: 10.1016/S0140-6736(18)32213-X. PMID: 30862377Free PMC Article
What We Have Learned From the Ocular Hypertension Treatment Study.
Gordon MO, Kass MA
Am J Ophthalmol 2018 May;189:xxiv-xxvii. Epub 2018 Mar 1 doi: 10.1016/j.ajo.2018.02.016. PMID: 29501371Free PMC Article
Central corneal thickness in glaucoma.
Sng CC, Ang M, Barton K
Curr Opin Ophthalmol 2017 Mar;28(2):120-126. doi: 10.1097/ICU.0000000000000335. PMID: 27764022

Recent systematic reviews

Topical corticosteroids for dry eye.
Liu SH, Saldanha IJ, Abraham AG, Rittiphairoj T, Hauswirth S, Gregory D, Ifantides C, Li T
Cochrane Database Syst Rev 2022 Oct 21;10(10):CD015070. doi: 10.1002/14651858.CD015070.pub2. PMID: 36269562Free PMC Article
Alcohol, Intraocular Pressure, and Open-Angle Glaucoma: A Systematic Review and Meta-analysis.
Stuart KV, Madjedi K, Luben RN, Chua SYL, Warwick AN, Chia M, Pasquale LR, Wiggs JL, Kang JH, Hysi PG, Tran JH, Foster PJ, Khawaja AP; Modifiable Risk Factors for Glaucoma Collaboration
Ophthalmology 2022 Jun;129(6):637-652. Epub 2022 Jan 31 doi: 10.1016/j.ophtha.2022.01.023. PMID: 35101531Free PMC Article
OCULAR HYPERTENSION AND GLAUCOMA FOLLOWING VITRECTOMY: A Systematic Review.
Miele A, Govetto A, Fumagalli C, Donati S, Biagini I, Azzolini C, Rizzo S, Virgili G
Retina 2018 May;38(5):883-890. doi: 10.1097/IAE.0000000000001651. PMID: 28426628
Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma: A Systematic Review and Network Meta-analysis.
Li T, Lindsley K, Rouse B, Hong H, Shi Q, Friedman DS, Wormald R, Dickersin K
Ophthalmology 2016 Jan;123(1):129-40. Epub 2015 Oct 31 doi: 10.1016/j.ophtha.2015.09.005. PMID: 26526633Free PMC Article
Glaucoma.
Shah R, Wormald RP
BMJ Clin Evid 2011 Jun 9;2011 PMID: 21658300Free PMC Article

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